생화학분자생물학회

	Hong-Duk Youn (hdyoun@snu.ac.kr)
	2001-present	Assistant/Associate/Full Professor, Dept Biochemistry & Molecular Biology, Seoul National University College of Medicine
	1996-2001	Post-doc associate Cancer Research Center, MIT, USA
	1995-1996	Post-doc associate, MCB, UC Berkeley, USA
	1990-1995	Ph.D., Dept Microbiology, College of Natural Sciences, Seoul National University
	1988-1990	MS, Dept Microbiology, College of Natural Sciences, Seoul National University
	1984-1988	Dept Microbiology, College of Natural Sciences, Seoul National University (BA)

Metabolic oxidoreductases: central regulators of the epigenetic landscapes in stemness

Cell metabolism has long been recognized as a fundamental process for energy production, biomolecule synthesis, and cell survival. During transitions between stem and somatic states, central carbon metabolism is rewired with concurrent changes in chromatin regulation and gene expression. Because a specific central carbon metabolic transition occurs simultaneously during the epigenetic transition from stem cells to somatic cells or vice versa, metabolism has an important role in determining the epigenetic landscape that influences cell fate. Oxidoreductases are key enzymes that catalyze oxidation-reduction reactions during central carbon metabolism. They also have important roles in determining the metabolic flux and epigenetic landscapes by supplying epigenetic metabolites, directly shaping chromatin structures through posttranslational modifications, and acting as scaffold proteins for epigenetic complexes to affect chromatin states. In this Review, we outline emerging mechanisms by which oxidoreductases couple metabolic flux to epigenetic landscapes that maintain or dissolve stemness.

Exp Mol Med. 2026 Apr;58(4):1017-1037. doi: 10.1038/s12276-026-01687-2
https://pubmed.ncbi.nlm.nih.gov/41974890/