생화학분자생물학회

	Jae Hun Shin ( jaehun.shin@yonsei.ac.kr )
	2025-Present	Associate Professor, Integrated Science & Engineering, Yonsei University
	2022-2024	Assistant Professor, Integrated Science & Engineering, Yonsei University
	2019-2022	Post.Doc, Dept. of Immunobiology, Interna Medicine, Yale University
	2012-2019	PhD, Dept. of Immunobiology, Yale University
	2008-2012	Research Assistant, National Cancer Center, Korea
	2002-2008	MS, BSE, Dept. of Biotechnology, Yonsei University

Trogocytosis-mediated immune evasion in the tumor microenvironment

Trogocytosis is a dynamic cellular process characterized by the exchange of plasma membrane and associated cytosol during cell-to-cell interactions. Unlike phagocytosis, this transfer maintains the surface localization of transferred membrane molecules. For instance, CD4 T cells engaging with antigen-presenting cells undergo trogocytosis, facilitating the transfer of antigen-loaded major histocompatibility complex (MHC) class II molecules from the antigen-presenting cells to CD4 T cells, resulting in the formation of antigen-loaded MHC class II molecule-dressed CD4 T cells. These "dressed" CD4 T cells subsequently participate in antigen presentation to other CD4 T cells. Additionally, trogocytosis enables the acquisition of immune-regulatory molecules such as CTLA-4 and Tim3 in recipient cells, thereby modulating their anti-tumor immunity. Concurrently, donor cells undergo plasma membrane loss, and substantial loss can trigger trogocytosis-mediated cell death, termed trogoptosis. This review aims to explore the trogocytosis-mediated transfer of immune regulatory molecules and its implications within the tumor microenvironment, elucidating the underlying mechanisms of immune evasion in cancers.

Exp Mol Med. 2025 Feb;57(1):1-12. doi: 10.1038/s12276-024-01364-2.
https://pubmed.ncbi.nlm.nih.gov/39741180/