생화학분자생물학회

	Eui-Cheol Shin ( ecshin@kaist.ac.kr )
	2007-present	Assistant Professor, Associate Professor, and Professor, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea
	2021-2024	Director, Center for Viral Immunology, Korea Virus Research Institute, Institute for Basic Science, Daejeon, Korea
	2002-2007	Postdoctoral Fellow, Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD, USA
	1996-2001	Ph.D., Yonsei University College of Medicine, Seoul, Korea
	1990-1996	M.D., Yonsei University College of Medicine, Seoul, Korea

Redefining the immune landscape of hepatitis A virus infection

Despite the development of effective vaccines against hepatitis A virus (HAV) infection, outbreaks of acute hepatitis A still occur globally, such that HAV remains a major cause of acute viral hepatitis. Most patients with acute hepatitis A recover spontaneously; however, some adult cases result in acute liver failure due to immune-mediated liver damage. Previous studies suggested that HAV evades the innate immune response through strong counteractive mechanisms, and that HAV-specific CD8+ T cells contribute to liver damage in patients with acute hepatitis A. However, recent research findings have led to revisions of old hypotheses. Here we will describe the most current knowledge regarding the innate immune response to HAV and the HAV-mediated counteractions against innate immune responses. Additionally, we will discuss the roles of various types of T cells in viral clearance and liver injury in patients with acute hepatitis A.

Exp Mol Med. 2025 Apr;57(4):714-723. https://doi.org/10.1038/s12276-025-01431-2.
https://pubmed.ncbi.nlm.nih.gov/40175697/