생화학분자생물학회

	Ji-Hwan Ryu ( yjh@yuhs.ac )
	2020-Present	Professor, Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Korea
	2015-2020	Associate Professor, Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Korea
	2009-2015	Assistant Professor, Research Center for Human Natural Defense System, Yonsei University College of Medicine, Seoul, Korea
	2006-2009	Research Professor, Division of Molecular Life Science, Ewha Woman’s University and National Creative Research Initiative Center for Symbiosystem, Seoul, Korea
	2005-2006	Staff Scientist, Laboratory of Innate Immunology, Institut Pasteur Korea, Seoul, Korea

Conversation between skin microbiota and the host: from early life to adulthood

Host life is inextricably linked to commensal microbiota, which play a crucial role in maintaining homeostasis and immune activation. A diverse array of commensal microbiota on the skin interacts with the host, influencing the skin physiology in various ways. Early-life exposure to commensal microbiota has long-lasting effects, and disruption of the epidermal barrier or transient exposure to these microorganisms can lead to skin dysbiosis and inflammation. Several commensal skin microbiota have the potential to function as either commensals or pathogens, both influencing and being influenced by the pathogenesis of skin inflammatory diseases. Here we explore the impact of various commensal skin microbiota on the host and elucidate the interactions between skin microbiota and host systems. A deeper understanding of these interactions may open new avenues for developing effective strategies to address skin diseases.

Exp Mol Med 2025 Apr;57(4):703-713. https://doi.org/10.1038/s12276-025-01427-y
https://pubmed.ncbi.nlm.nih.gov/40164684/