생화학분자생물학회

	Soo Seok Hwang ( sshwang@snu.ac.kr )
	2023 -	Assistant Professor, School ofBiological Sciences, Seoul National University, Seoul, South Korea
	2021-2023	Assistant Professor, Department ofBiochemistry and Molecular Biology, Yonsei University College of Medicine,Seoul, SouthKorea
	2020-2021	Associate Research Scientist, Department ofImmunobiology, Yale University School of Medicine, New Haven, U.S.
	2015-2020	Postdoctoral Fellow, Department ofImmunobiology, Yale University School of Medicine, New Haven, U.S.
	2013-2014	Research Professor, Department of LifeScience, Sogang University, Seoul, South Korea
	2007-2013	Ph.D. Immunology,Department of Life Science, Sogang University, Seoul, South Korea
	2001-2007	B.S./B.A. Life Science /Business Administration, (Double major) Sogang University, Seoul, South Korea

Guardians of silence: transcriptional networks in T cell quiescence

The maintenance of quiescence in T cells plays a pivotal role in averting undesired immune reactions and fostering immune homeostasis. Upon receiving external signals of cognate antigen and costimulatory molecules, T cells escape a quiescent state and rapidly proliferate within an exceedingly short timeframe. Nevertheless, for the majority of their lifespan, T cells remain inactive before stimulation, yet they are highly poised to future activation, implicating the presence of dynamic and intricate regulatory processes in a seemingly dormant state. While numerous extrinsic cues have been identified to induce T cell activation from a quiescence currently, intrinsic mechanisms governing T cell quiescence have received limited attention. Here we provide a comprehensive overview of multiple factors involved in T cell quiescence and their molecular mechanisms mainly in the context of transcriptional and post-transcriptional regulation. Given the intricate interplay between the control of T cell quiescence and a variety of diseases including autoimmunity, exhaustion and even tumor control, a thorough understanding of current insights into T cell quiescence affords us a valuable opportunity to advance our comprehension of T cell biology.

Exp Mol Med. 2025 Aug;57(8):1663-1672. https://doi.org/10.1038/s12276-025-01516-y.
https://pubmed.ncbi.nlm.nih.gov/40759740/