생화학분자생물학회

	Name: Baofang Cui ( baofangcui@yonsei.ac.kr )
	2019-present	Ph.D. Candidate, Department of Biotechnology, Yonsei University
	2015-2019	B.S., Department of Biotechnology, Yonsei University
	Name: Seung-Woo Cho ( seungwoocho@yonsei.ac.kr )
	2010-present	Professor, Department of Biotechnology, Yonsei University
	2007-2009	Postdoctoral Associate, Massachusetts Institute of Technology, USA
	2001-2006	Ph.D., School of Chemical Engineering, Seoul National University
	1999-2001	M.S., School of Chemical Engineering, Seoul National University
	1995-1999	B.S., School of Chemical Engineering, Seoul National University

Blood-brain barrier-on-a-chip for brain disease modeling and drug testing

The blood-brain barrier (BBB) is an interface between cerebral blood and the brain parenchyma. As a gate keeper, BBB regulates passage of nutrients and exogeneous compounds. Owing to this highly selective barrier, many drugs targeting brain diseases are not likely to pass through the BBB. Thus, a large amount of time and cost have been paid for the development of BBB targeted therapeutics. However, many drugs validated in in vitro models and animal models have failed in clinical trials primarily due to the lack of an appropriate BBB model. Human BBB has a unique cellular architecture. Different physiologies between human and animal BBB hinder the prediction of drug responses. Therefore, a more physiologically relevant alternative BBB model needs to be developed. In this review, we summarize major features of human BBB and current BBB models and describe organ-on-chip models for BBB modeling and their applications in neurological complications.


BMB Rep. 2022 May;55(5):213-219.
https://pubmed.ncbi.nlm.nih.gov/35410642/