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BmB Reports

A new layer of the Golgi complex : membrane trafficking, glycosylation and signaling transduction

  • 작성자

    Seung-Yeol Park
  • 작성일자

    2021-03-22
  • 조회수

    1
Name: Seung-Yeol Park ( seungpark@postech.ac.kr )
2019-present Assistant Professor, Department of Life Sciences, POSTECH
2017-2019 Instructor, Brigham and Women’s Hospital & Harvard Medical School, USA
2011-2017 Postdoctoral fellow, Brigham and Women’s Hospital & Harvard Medical School, USA
2006-2011 Ph.D., Department of Biological Sciences, KAIST

A new layer of the Golgi complex : membrane trafficking, glycosylation and signaling transduction

The Golgi complex plays a central role in the secretory pathway by regulating sorting, trafficking and post-translational modification of secretory cargoes. It is structurally a unique which consists of several stacks, as known as cisternae. Morphologic change has been found in various physiological and pathological conditions including cancer, immunodeficiency and neurodegenerative disease. These changes affect the functional alteration in glycosylation and membrane trafficking of secretory proteins. Thus, there is long-standing question about the cause and effect between morphologic change and functional alteration of the Golgi complex. This review summarizes a journey to understanding how the Golgi complex acts in many cellular events. These include the molecular mechanisms and physiologic importance of the secretory pathway. Moreover, we review recent findings that the Golgi complex regulates multiple signaling pathways for organelle homeostasis.


https://pubmed.ncbi.nlm.nih.gov/33612152/
BMB Rep. 2021 Feb 22;5256. Online ahead of print.