생화학분자생물학회

	Name: Cheil Moon ( cmoon@dgist.ac.kr )
	2009-present	Professor, Department of Brain & Cognitive Sciences, DGIST, ROK
	2005-2009	Assistant Professor, Department of Oral Anatomy & Neurobiology, Kyungpook National University, ROK
	2005-2005	Instructor, Johns Hopkins University, USA
	1999-2005	Research Associate, Johns Hopkins University, USA
	1994-1999	Postdoctoral research fellow, Johns Hopkins University, USA
	1997-2004	Ph.D., Department of Biology, Imperial College, UK.

Olfactory pathology in Alzheimer’s disease: a sign of ongoing neurodegeneration

Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory dysfunction is also associated with memory and cognitive dysfunction and is an incidental finding of AD dementia. Here we review neuropathological research on the olfactory system in AD, considering both structural and functional evidence. Experimental and clinical findings identify olfactory dysfunction as an early indicator of AD. In keeping with this, amyloid-β production and neuroinflammation are related to underlying causes of impaired olfaction. Notably, physiological features of the spatial map in the olfactory system suggest the evidence of ongoing neurodegeneration. Our aim in this review is to examine olfactory pathology findings essential to identifying mechanisms of olfactory dysfunction in the development of AD in hopes of supporting investigations leading towards revealing potential diagnostic methods and causes of early pathogenesis in the olfactory system.


BMB Rep 2021 Jun;54(6):295-304.
https://pubmed.ncbi.nlm.nih.gov/34162463/