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BmB Reports

Olfactory pathology in Alzheimer’s disease: a sign of ongoing neurodegeneration

  • 작성자

    Cheil Moon
  • 작성일자

    2021-07-15
  • 조회수

    2
Name: Cheil Moon ( cmoon@dgist.ac.kr )
2009-present Professor, Department of Brain & Cognitive Sciences, DGIST, ROK
2005-2009 Assistant Professor, Department of Oral Anatomy & Neurobiology, Kyungpook National University, ROK
2005-2005 Instructor, Johns Hopkins University, USA
1999-2005 Research Associate, Johns Hopkins University, USA
1994-1999 Postdoctoral research fellow, Johns Hopkins University, USA
1997-2004 Ph.D., Department of Biology, Imperial College, UK.

Olfactory pathology in Alzheimer’s disease: a sign of ongoing neurodegeneration

Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory dysfunction is also associated with memory and cognitive dysfunction and is an incidental finding of AD dementia. Here we review neuropathological research on the olfactory system in AD, considering both structural and functional evidence. Experimental and clinical findings identify olfactory dysfunction as an early indicator of AD. In keeping with this, amyloid-β production and neuroinflammation are related to underlying causes of impaired olfaction. Notably, physiological features of the spatial map in the olfactory system suggest the evidence of ongoing neurodegeneration. Our aim in this review is to examine olfactory pathology findings essential to identifying mechanisms of olfactory dysfunction in the development of AD in hopes of supporting investigations leading towards revealing potential diagnostic methods and causes of early pathogenesis in the olfactory system.


BMB Rep 2021 Jun;54(6):295-304.
https://pubmed.ncbi.nlm.nih.gov/34162463/