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BmB Reports

The role of NUMB/ NUMB isoforms in Cancer Stem and Stem Cells

  • 작성자

    Hye Yeon Choi
  • 작성일자

    2021-07-15
  • 조회수

    2
Name: Hye Yeon Choi ( choi647@usc.edu )
2019-present Research associate, University of Southern California, USA
2018-2019 Postdoc scholar, University of Southern California, USA
2017-2018 Academic research professor, Konkuk University
2014-2017 Postdoc, Animal Resources Research Center, Konkuk University
2006-2014 Ph.D., Department of Animal Biotechnology, Konkuk University

The role of NUMB/ NUMB isoforms in Cancer Stem and Stem Cells

Cancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss of NUMB expression leads to uncontrolled proliferation and amplification of the CSC pool, which promotes the Notch signaling pathway and reduces the expression of the p53 protein. NUMB genes are alternatively spliced to produce six functionally distinct isoforms. An interesting recent discovery is that the protein NUMB isoform produced by alternative splicing of NUMB plays an important role in promoting carcinogenesis. In this review, we summarize the known functions of NUMB and NUMB isoforms related to the proliferation and generation of CSCs.


BMB Rep 2021 Jun 3;5340. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34078527/