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BmB Reports

Biomaterials-assisted spheroid engineering for regenerative therapy

  • 작성자

    Hye Sung Kim
  • 작성일자

    2021-07-15
  • 조회수

    4
Name: Hye Sung Kim ( hskim1213@dankook.ac.kr )
2020-present Research Assistant Professor, Institute of Tissue Regeneration Engineering, Dankook University
2016-2020 Postdoctoral Research Fellow, Department of Biomedical Engineering, Columbia University, USA
2016-2016 Senior Research Scientist, Institute of Bioscience & Bioengineering
2010-2015 Ph.D., Department of Biomaterials Engineering, Kangwon National University

Biomaterials-assisted spheroid engineering for regenerative therapy

Cell-based therapy is a promising approach in the field of regenerative medicine. As cells are formed into spheroids, their survival, functions, and engraftment in the transplanted site are significantly improved as compared to single cells transplantation. To improve the therapeutic effect of cell spheroids even further, various biomaterials (e.g. nano- or microparticles, fibers and hydrogels) have been developed for spheroid engineering. The biomaterials not only control overall spheroid formation (e.g. size, shape, aggregation speed, and degree of compaction), but also regulate cell-to-cell and cell-to-matrix interactions in spheroids. Therefore, cell spheroids in synergy with the biomaterials have recently emerged for cell-based regenerative therapy. Biomaterials-assisted spheroid engineering has been extensively studied for regeneration of bone or/and cartilage defects, critical limb ischemia and myocardial infarction. Furthermore, it has been expanding to pancreas islets and hair follicle transplantation. This mini review comprehensively reviews biomaterials-assisted spheroid engineering for regenerative therapy.


BMB Rep 2021 Jun 22;5359. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34154700/