생화학분자생물학회입니다.
Blood-brain barrier-on-a-chip for brain disease modeling and drug testing
작성자
Baofang Cui작성일자
2022-07-19조회수
90Name: Baofang Cui ( baofangcui@yonsei.ac.kr ) | ||
2019-present | Ph.D. Candidate, Department of Biotechnology, Yonsei University | |
2015-2019 | B.S., Department of Biotechnology, Yonsei University | |
Name: Seung-Woo Cho ( seungwoocho@yonsei.ac.kr ) | ||
2010-present | Professor, Department of Biotechnology, Yonsei University | |
2007-2009 | Postdoctoral Associate, Massachusetts Institute of Technology, USA | |
2001-2006 | Ph.D., School of Chemical Engineering, Seoul National University | |
1999-2001 | M.S., School of Chemical Engineering, Seoul National University | |
1995-1999 | B.S., School of Chemical Engineering, Seoul National University |
Blood-brain barrier-on-a-chip for brain disease modeling and drug testing
The blood-brain barrier (BBB) is an interface between cerebral blood and the brain parenchyma. As a gate keeper, BBB regulates passage of nutrients and exogeneous compounds. Owing to this highly selective barrier, many drugs targeting brain diseases are not likely to pass through the BBB. Thus, a large amount of time and cost have been paid for the development of BBB targeted therapeutics. However, many drugs validated in in vitro models and animal models have failed in clinical trials primarily due to the lack of an appropriate BBB model. Human BBB has a unique cellular architecture. Different physiologies between human and animal BBB hinder the prediction of drug responses. Therefore, a more physiologically relevant alternative BBB model needs to be developed. In this review, we summarize major features of human BBB and current BBB models and describe organ-on-chip models for BBB modeling and their applications in neurological complications.
BMB Rep. 2022 May;55(5):213-219.
https://pubmed.ncbi.nlm.nih.gov/35410642/