생화학분자생물학회

	Jee-Yin Ahn ( jeeahn@skku.edu )
	2005 - present	Assistant/ Associate/Full Professor, Department of Molecular Cell Biology, Sungkyunkwan University, School of medicine, South Korea
	2011 - 2012	Visiting Professor, Department of Neurology, University of California, San Francisco (UCSF)
	2002 - 2005	Post-Doctoral Fellow, Emory University School of Medicine

The roles of multifunctional protein ErbB3 binding protein 1 (EBP1) isoforms from development to disease

The roles of the two isoforms of ErbB3-binding protein 1 (Ebp1) in cellular function and its regulation in disease and development is a stimulating area in current fields of biology, such as neuroscience, cancer biology, and structural biology. Over the last two decades, a growing body of studies suggests have suggested different functions for the EBP1 isoforms in various cancers, along with their specific binding partners in the ubiquitin-proteasome system. Owing to the specific cellular context or spatial/temporal expression of the EBP1 isoforms, either transcriptional repression or the activation function of EBP1 has been proposed, and epigenetic regulation by p48 EBP1 has also been observed during in the embryo development, including in brain development and neurologic disorders, such as schizophrenia, in using an Ebp1 knockout mouse model. Here, we review recent findings that have shaped our current understanding of the emerging function of EBP1 isoforms in cellular events and gene expression, from development to disease.

2020 Jul;52(7):1039-1047. doi: 10.1038/s12276-020-0476-z.
PMID: 32719408 PMCID: PMC8080562 DOI: 10.1038/s12276-020-0476-z