생화학분자생물학회

	Hiroshi HARADA ( harada.hiroshi.5e@kyoto-u.ac.jp )
	2019 - present	Director, Radiation Biology Center, Kyoto University, Japan
	2018-Present	Professor, Graduate School of Biostudies, Kyoto University, Japan
	2016-Present	Professor, Radiation Biology Center, Kyoto University, Japan
	2015-2016	Associate Professor, Hakubi Center, Kyoto University, Japan
	2014	Visiting Scientist, MRC/CRUK Oxford Institute for Radiation Biology and Oncology, University of Oxford, UK
	2013-2015	Associate Professor, Graduate School of Medicine, Kyoto University, Japan
	2009-2013	Group Leader/Lecturer (PI), Career Path Promotion Unit for Young Life Scientists, Kyoto University, Japan
	2008-2009	Lecturer, Graduate School of Medicine, Kyoto University, Japan
	2003-2008	Assistant Professor, Graduate School of Medicine, Kyoto University, Japan
	1998-2003	Research Scientist, POLA Chemical Industry, Inc. Japan
	2002	Ph.D. Division of Biological Science, Graduate School of Science, Nagoya University, Japan
	1998	M.S. Division of Biological Science, Graduate School of Science, Nagoya University, Japan
	1996	B.S. Division of Molecular Biology, School of Science, Nagoya University, Japan

Tumor microenvironment and radioresistance

Metastasis is not the result of a random event, as cancer cells can sustain and proliferate actively only in a suitable tissue microenvironment and then form metastases. Since Dr. Stephen Paget in the United Kingdom proposed the seed and soil hypothesis of cancer metastasis based on the analogy that plant seeds germinate and grow only in appropriate soil, considerable attention has focused on both extracellular environmental factors that affect the growth of cancer cells and the tissue structure that influences the microenvironment. Malignant tumor tissues consist of not only cancer cells but also a wide variety of other cells responsible for the inflammatory response, formation of blood vessels, immune response, and support of the tumor tissue architecture, forming a complex cellular society. It is also known that the amounts of oxygen and nutrients supplied to each cell differ depending on the distance from tumor blood vessels in tumor tissue. Here, we provide an overview of the tumor microenvironment and characteristics of tumor tissues, both of which affect the malignant phenotypes and radioresistance of cancer cells, focusing on the following keywords: diversity of oxygen and nutrient microenvironment in tumor tissue, inflammation, immunity, and tumor vasculature.

Exp Mol Med. 2021 Jun 16. doi: 10.1038/s12276-021-00640-9. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34135469/