생화학분자생물학회

	Jong-Woo Sohn ( jwsohn@kaist.ac.kr )
	2014-present	Assistant & Associate Professor, Department of Biological Sciences, KAIST, Daejeon, South Korea
	2009-2014	Postdoctoral Researcher, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
	2008-2009	Postdoctoral Fellow, BK21 Research Division of Human Life Science, Seoul National University, Seoul, South Korea
	2003-2008	Teaching Assistant, Department of Physiology, Seoul National University College of Medicine, Seoul, South Korea
	2003-2008	PhD, Department of Physiology, Seoul National University College of Medicine, Seoul, South Korea
	1997-2003	MD, Seoul National University College of Medicine, Seoul, South Korea

Neuroendocrine control of appetite and metabolism

Abstract of your review article Body homeostasis is predominantly controlled by hormones secreted by endocrine organs. The central nervous system contains several important endocrine structures, including the hypothalamic-pituitary axis. Conventionally, neurohormones released by the hypothalamus and the pituitary gland (hypophysis) have received much attention owing to the unique functions of the end hormones released by their target peripheral organs (e.g., glucocorticoids released by the adrenal glands). Recent advances in mouse genetics have revealed several important metabolic functions of hypothalamic neurohormone-expressing cells, many of which are not readily explained by the action of the corresponding classical downstream hormones. Notably, the newly identified functions are better explained by the action of conventional neurotransmitters (e.g., glutamate and GABA) that constitute a neuronal circuit. In this review, we discuss the regulation of appetite and metabolism by hypothalamic neurohormone-expressing cells, with a focus on the distinct contributions of neurohormones and neurotransmitters released by these neurons.

Exp Mol Med. 2021 Apr;53(4):505-516. doi: 10.1038/s12276-021-00597-9.
https://pubmed.ncbi.nlm.nih.gov/33837263/