생화학분자생물학회입니다.
Advanced principles and technologies in higher order chromatin architecture: move towards the 4D genome
작성자
Namyoung Jung작성일자
2021-07-15조회수
380Name: Namyoung Jung ( jnamyoun@postech.ac.kr ) | ||
2020-present | Postdoctoral research fellow, Department of Life Science, Pohang University of Science and Technology (POSTECH) | |
2016-2020 | Postdoctoral research fellow, Department of Dermatology, Stanford University School of Medicine, USA | |
2009-2015 | Ph.D., Cellular and molecular Medicine, Johns Hopkins University School of Medicine, USA | |
Name: Tae-Kyung Kim ( tkkim@postech.ac.kr ) | ||
2018-present | Associate Professor, Department of Life Science, Pohang University of Science and Technology (POSTECH) | |
2010-2018 | Assistant/Associate Professor, Department of Neurosciences, University of Texas Southwestern Medical Center, USA | |
2002-2009 | Postdoctoral research fellow, Department of Neurobiology, Harvard Medical School | |
1993-2001 | Ph.D., Department of Biochemistry, Rutgers University Medical School, USA |
Advanced principles and technologies in higher order chromatin architecture: move towards the 4D genome
In eukaryotes, the genome is hierarchically packed inside the nucleus, which facilitates physical contact between cis-regulatory elements (CREs), such as enhancers and promoters. Accumulating evidence highlights the critical role of higherorder chromatin structure in precise regulation of spatiotemporal gene expression under diverse biological contexts including lineage commitment and cell activation by external stimulus. Genomics and imaging-based technologies, such as Hi-C and DNA fluorescence in situ hybridization (FISH), have revealed the key principles of genome folding, while newly developed tools focus on improvement in resolution, throughput and modality at single-cell and population levels, and challenge the knowledge obtained through conventional approaches. In this review, we discuss recent advances in our understanding of principles of higher-order chromosome conformation and technologies to investigate 4D chromatin interactions.
BMB Rep 2021 May;54(5):233-245. doi: 10.5483/BMBRep.2021.54.5.035.
https://pubmed.ncbi.nlm.nih.gov/33972012/