생화학분자생물학회

	Name: Min-Kyoo Shin ( minkyooshin@snu.ac.kr )
	2022-present	Assistant Professor, College of Pharmacy, Seoul National University
	2018-2022	Senior Research Associate/Research Scientist, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, USA
	2015-2017	Postdoctoral research scholar, University of Iowa, USA
	2009-2014	Ph.D., Department of Biological Sciences, Sungkyunkwan University

Decoding tau acetylation in Alzheimer’s disease and tauopathies: from site-specific mechanisms to therapeutic horizons

Tau acetylation has emerged as a critical post-translational modification implicated in the pathogenesis of Alzheimer’s disease (AD) and other tauopathies. This review provides a comprehensive synthesis of current knowledge on site-specific tau acetylation, its regulatory enzymes, and its multifaceted effects on tau biology. Acetylation modulates tau degradation, aggregation, propagation, and microtubule-binding properties in a residue-specific manner, often in concert with other modifications such as phosphorylation and ubiquitination. The review also highlights emerging therapeutic strategies targeting tau acetylation, including small-molecule inhibitors of p300/CBP and monoclonal antibodies against acetylated tau epitopes. Although several of these approaches are currently undergoing clinical evaluation, many acetylation sites remain poorly characterized, underscoring the need for further mechanistic studies. Advancing our understanding of tau acetylation will be critical for developing targeted interventions aimed at halting or reversing tau-driven neurodegeneration.


BMB Rep. 2025 Jul 10:6515. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/40635200/