생화학분자생물학회

	Name: Kyung A Cho ( kacho@jnu.ac.kr )
	2015-present	Professor, Department of Biochemistry, Chonnam National University Medical School, South Korea
	2020-present	Founder & CEO, Medispan., Inc
	2020-2022	Vice President, Chonnam National University Medical School, South Korea
	2015-present	Professor, Department of Biochemistry, Chonnam National University Medical School, South Korea
	2010-2015	Associate Professor, Department of Biochemistry, Chonnam National University Medical School, South Korea
	2006-2010	Assistant Professor, Department of Biochemistry, Chonnam National University Medical School, South Korea
	2002-2006	Post-Doc, Department of Biochemistry, Seoul National University College of Medicine, , South Korea
	2002-2006	PhD, Department of Biochemistry, Seoul National University College of Medicine

Targeting immunosenescence and inflammaging: advancing longevity research

Here we examine the crucial role of the immune system in aging, with a particular focus on two interconnected processes: immunosenescence and inflammaging, which contribute to age-related decline. Our goal is to provide a thorough overview of the various factors that lead to immune aging while introducing therapeutic approaches that can partially restore immune function. Additionally, we discuss recent strategies that go beyond localized immune improvement to actively modulate immune balance, influencing systemic aging and extending healthspan. Through this exploration, we propose that regulating the immune system is essential for managing immune aging and may serve as a key mechanism for controlling the overall aging process and promotinghealthy longevity.


Exp Mol Med. 2025 Sep; 57(9):1881 – 1892. doi: 10.1038/s12276-025-01527-9
https://pubmed.ncbi.nlm.nih.gov/40887496/