생화학분자생물학회

	Name: Inhak Choi ( miccih@inje.ac.kr )
	2008-present	Professor, Department of Microbiology and Immunology, Inje University College of Medicine
	2001-2003	Postdoctoral research fellow, Mayo Clinic, USA
	1989-1993	Ph.D., Department of Microbiology, Seoul National University, College of Medicine, Korea
	1981-1987	M.D. Inje University College of Medicine

Current understanding on cancer-intrinsic PD-L1: regulation of expression and its protumoral activity

Overexpression of programmed cell death ligand 1 (PD-L1) in cancer cells promotes cancer progression by suppressing tumor-specific T cells in tumor microenvironment and exerting protumoral activity that involves mesenchymal transition, glucose and lipid metabolism, stemness, and autophagy. Here we review the current understanding on the regulation of expression and intrinsic protumoral activity of cancer-intrinsic PD-L1.


BMB Rep 2020 Dec 11;5223. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33298250/