생화학분자생물학회

	Name: Seung-Woo Lee ( sw_lee@postech.ac.kr )
	2012-present	Associate Professor, Department of life Sciences, POSTECH, Korea
	2009-2011	Research scientist, La Jolla Institute for Allergy and Immunology, USA
	2003-2008	Postdoctoral fellow, La Jolla Institute for Allergy and Immunology, USA
	1993-1999	Ph.D., Department of life Sciences, POSTECH, Korea

Cancer Immunotherapy with T-cell targeting cytokines: IL-2 and IL-7

Clinical trials have demonstrated that an increased number of effector cells, especially tumor-specific T cells, is positively linked with patients' prognosis. Although the discovery of checkpoint inhibitors (CPIs) has emerged the encouraging progress of cancer immunotherapy, lack of T cells, the target for CPIs, is known as one of the limitations of patients with poor prognosis. Since the interleukin (IL)-2 and IL-7 are cytokines that are well-known to target many aspects of T cell responses, they have been used in the treatment of cancers. In this review, we focus on the basic biology of how these cytokines modulate T cell response and the clinical trials using the cytokines against cancers. Furthermore, we introduce several recent works that aim to improve cytokines' biological activities and find the strategy for combination with other therapeutics.