생화학분자생물학회

	Name: Kwon-Yul Ryu ( kyryu@uos.ac.kr )
	2017-present	Professor, Department of Life Science, University of Seoul
	2012-2017	2012-2017 Associate Professor, Department of Life Science, University of Seoul
	2008-2012	Assistant Professor, Department of Life Science, University of Seoul
	2005-2008	Research Associate, Stanford University, USA
	2001-2005	Post-doctoral Research Fellow, Stanford University, USA
	1995-2001	Ph.D., Ohio State Biochemistry Program, The Ohio State University, USA

Regulation of polyubiquitin genes to meet cellular ubiquitin requirement

Ubiquitin (Ub) is one of the highly conserved protein from yeast to humans. It is an essential core unit of the well-defined post-translational modification, called ubiquitination, which is involved in a variety of biological processes. In metazoans, Ub is encoded by two monoubiquitin genes and two polyubiquitin genes, in which single Ub is fused to a ribosomal protein or Ub coding units are arranged in tandem repeats, respectively. In mice, polyubiquitin genes (Ubb and Ubc) have been shown to play a pivotal role to meet the requirement of cellular Ub pools during embryonic development. In addition, expression levels of polyubiquitin genes are increased to adapt environmental stimuli such as oxidative, heat-shock, and proteotoxic stress. Several researchers have reported about the perturbation of Ub pools through genetic alteration or exogenous Ub delivery using diverse model systems. To study Ub pool changes in a physiologically relevant manner, it has recently been introduced to change Ub pools via the regulation of endogenous polyubiquitin gene expression. Furthermore, to understand the regulation of polyubiquitin gene expression more precisely, cis-acting elements and trans-acting factors, which are regulatory components of polyubiquitin genes, have been analyzed. In this review, we discussed how the role of polyubiquitin genes has been studied during the past decade, especially focusing on their regulation.


https://pubmed.ncbi.nlm.nih.gov/33612153/
BMB Rep. 2021 Feb 22;5276. Online ahead of print.