생화학분자생물학회

	Youngmi Jung (y.jung@pusan.ac.kr)
	2014-present	Associate Professor, Department of Biology, Pusan National University, South Korea
	2010-2014	Assistant Professor, Department of Biology, Pusan National University, South Korea
	2008-2010	Assistant Professor, Department of Medicine, Division of Gastroenterology, Duke University, USA
	2006-2008	Research Associate, Department of Medicine, Division of Gastroenterology, Duke University, USA
	2002-2006	PhD, College of Medicine, Department of Pathology, Immunology, and laboratory medicine, University of Florida, USA
	1997-1999	MS, College of Medicine, Department of Pathology, Seoul National University, South Korea

Radiation-induced liver disease: current understanding and future perspectives

Although radiotherapy (RT) is used for the treatment of cancers including liver cancer, radiation-induced liver disease (RILD) has emerged as a major limitation of RT. Radiation-induced toxicities on nontumorous liver tissues are associated with the development of numerous symptoms which may limit the course of therapy or have serious chronic side effects including late fibrosis. Although the clinical characteristics of RILD patients have been relatively well described, understanding of RILD pathogenesis has been hampered by a lack of reliable animal models for RILD. Despite efforts to develop suitable experimental animal models for RILD, current animal models rarely present hepatic veno-occlusive disease, the pathological hallmark of human RILD patients, giving highly variable results in RILD-related studies. Herein, we introduce the concept and clinical characteristics of RILD and put forward a feasible explanation for RILD pathogenesis. In addition, currently available animal models of RILD are reviewed, focusing on their similarity with human RILD and clues to understanding the mechanisms of RILD progression. Based on these findings from RILD research, we present potential therapeutic strategies against RILD and prospects for future RILD studies. Therefore, this review helps to broaden our understanding in developing effective treatment strategies for RILD.

Exp Mol Med. 2017 Jul 21;49(7):e359. doi: 10.1038/emm.2017.85.
https://www.ncbi.nlm.nih.gov/pubmed/28729640