생화학분자생물학회

	Joon Kim (joonkim@kaist.ac.kr)
	2015-present	Associate Professor, Graduate School of Medical Science & Engineering, KAIST, South Korea
	2010-2015	Assistant Professor, Graduate School of Medical Science & Engineering, KAIST, South Korea
	2006-2010	Postdoctoral Fellow, Department of Neurosciences, UCSD, USA
	2001-2006	PhD, Department of Anatomy and Neurobiology, UCI, USA

The potential role of YAP in head and neck squamous cell carcinoma

Transcriptional cofactor YAP and its inhibitory regulators, Hippo kinases and adaptor proteins, constitute an evolutionarily conserved signaling pathway that control organ size and cell fate. The activity of the Hippo-YAP pathway is determined by a variety of intracellular and intercellular cues, such as cell polarity, junction, density, mechanical stress, energy status and growth factor signaling. Recent studies have demonstrated that YAP can induce the expression of a set of genes that allow cancer cells to gain survival advantage and aggressive behavior. Comprehensive genomic studies have revealed frequent focal amplifications of the YAP locus in human carcinomas, including head and neck squamous cell carcinoma (HNSCC). Moreover, FAT1, which encodes an upstream component of Hippo signaling, is one of the most commonly altered genes in HNSCC. In this review, we discuss causes and functional consequences of YAP dysregulation in HNSCC. We also address interactions between YAP and other oncogenic drivers of HNSCC.

Exp Mol Med. 2020 Aug;52(8):1264-1274. doi: 10.1038/s12276-020-00492-9.
https://pubmed.ncbi.nlm.nih.gov/32859951/