생화학분자생물학회입니다.
Heterochromatin: an epigenetic point of view in aging
작성자
관리자작성일자
2020-11-23조회수
138Jong-Hyuk Lee (Jong-Hyuk.lee@nih.gov) | ||
2016-present | Postdoctoral Research Scientist, National Institute on Aging,National institute of Health, USA | |
2009-2015 | Ph.D., Biomedical Science, Department of Biomedical Science, Seoul National University, South Korea | |
2006-2009 | M.S., Genetic engineering, Department of Natural Sciences, Seoul National University, South Korea |
Heterochromatin: an epigenetic point of view in aging
Aging is an inevitable process of life. Defined by progressive physiological and functional loss of tissues and organs, aging increases the risk of mortality for the organism. The aging process is affected by various factors, including genetic and epigenetic ones. Here, we review the chromatin-specific epigenetic changes that occur during normal (chronological) aging and in premature aging diseases. Taking advantage of the reversible nature of epigenetic modifications, we will also discuss possible lifespan expansion strategies through epigenetic modulation, which was considered irreversible until recently.
Exp Mol Med. 2020 Sep 4. doi: 10.1038/s12276-020-00497-4. Online ahead of print.
https://www.ncbi.nlm.nih.gov/pubmed/32887933