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DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells

  • 작성자

    관리자
  • 작성일자

    2020-12-23
  • 조회수

    119
Zhenkun Lou ( Lou.zhenkun@mayo.edu )
2013-present Professor, Department of Pharmacology, Mayo Clinic
2012-present Consultant, Division of Oncology Research, Department of Oncology, Mayo Clinic.
2011-present Co-Chair, Developmental Therapeutics Program, Mayo Clinic Cancer Center
2009-2012 Associate Professor, Department of Pharmacology, Mayo Clinic
2009-2012 Senior Associate Consultant, Division of Oncology Research, Department of Oncology, Mayo Clinic
2006-2009 Assistant Professor and Associate Consultant, Division of Oncology Research, Department of Oncology, Mayo Clinic
2001-2006 Postdoctoral Research Fellow, Department of Oncology, Mayo Medical Center
1992-1995 Research Fellow, Shanghai Research Center for Biotechnology, Academia SINICA, Shanghai, China.

DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells

DNA end resection has a key role in double-strand break repair and DNA replication. Defective DNA end resection can cause malfunctions in DNA repair and replication, leading to greater genomic instability. DNA end resection is initiated by MRN-CtIP generating short, 3'-single-stranded DNA (ssDNA). This newly generated ssDNA is further elongated by multiple nucleases and DNA helicases, such as EXO1, DNA2, and BLM. Effective DNA end resection is essential for error-free homologous recombination DNA repair, the degradation of incorrectly replicated DNA and double-strand break repair choice. Because of its importance in DNA repair, DNA end resection is strictly regulated. Numerous mechanisms have been reported to regulate the initiation, extension, and termination of DNA end resection. Here, we review the general process of DNA end resection and its role in DNA replication and repair pathway choice..


Exp Mol Med. 2020 Oct;52(10):1705-1714. doi: 10.1038/s12276-020-00519-1.
https://pubmed.ncbi.nlm.nih.gov/33122806/