생화학분자생물학회

	Chang-Jun Cha ( cjcha@cau.ac.kr )
	2004-present	Professor, Department of Systems Biotechnology, Chung-Ang University, South Korea
	2001-2004	Research professor, BK21 Division of Life Science, Seoul National University, South Korea
	1998-2001	Postdoctoral research fellow, National Center for Toxicological Research, U.S. Food and Drug Administration, USA
	1992-1997	PhD, Institute of Biotechnology, University of Cambridge, UK
	1986-1990	BSc, Department of Microbiology, Seoul National University, South Korea

Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission

The concept of the antibiotic resistome was introduced just over a decade ago, and since then, active resistome studies have been conducted. In the present study, we describe the previously established concept of the resistome, which encompasses all types of antibiotic resistance genes (ARGs), and the important findings from each One-Health sector considering this concept, thereby emphasizing the significance of the One-Health approach in understanding ARG transmission. Cutting-edge research methodologies are essential for deciphering the complex resistome structure in the microbiomes of humans, animals and the environment. Based on the recent achievements of resistome studies in multiple One-Health sectors, future directions for resistome research have been suggested to improve the understanding and control of ARG transmission: (1) ranking the critical ARGs and their hosts; (2) understanding ARG transmission at the interfaces of One-Health sectors; (3) identifying selective pressures affecting the emergence, transmission, and evolution of ARGs; and (4) elucidating the mechanisms that allow an organism to overcome taxonomic barriers in ARG transmission.


Exp Mol Med. 2021 Mar 1. doi: 10.1038/s12276-021-00569-z

https://pubmed.ncbi.nlm.nih.gov/33642573/