생화학분자생물학회입니다.
Zebrafish as an animal model for biomedical research
작성자
Cheol-Hee Kim작성일자
2021-03-23조회수
133Cheol-Hee Kim( zebrakim@cnu.ac.kr ) | ||
2001-present | Professor, Department of Biology, Chungnam National University, South Korea | |
1998-2001 | Visiting fellow, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, USA | |
1993-1997 | PhD, Department of Pharmacology, Osaka University Medical School, Japan | |
1985-1992 | BS, MS, Department of Genetic Engineering, Kyungpook National University, South Korea |
Zebrafish as an animal model for biomedical research
Zebrafish have several advantages compared to other vertebrate models used in modeling human diseases, particularly for large-scale genetic mutant and therapeutic compound screenings, and other biomedical research applications. With the impactful developments of CRISPR and next-generation sequencing technology, disease modeling in zebrafish is accelerating the understanding of the molecular mechanisms of human genetic diseases. These efforts are fundamental for the future of precision medicine because they provide new diagnostic and therapeutic solutions. This review focuses on zebrafish disease models for biomedical research, mainly in developmental disorders, mental disorders, and metabolic diseases.
Exp Mol Med. 2021 Mar 1. doi: 10.1038/s12276-021-00571-5.
https://pubmed.ncbi.nlm.nih.gov/33649498/