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Zebrafish as an animal model for biomedical research

  • 작성자

    Cheol-Hee Kim
  • 작성일자

    2021-03-23
  • 조회수

    133
Cheol-Hee Kim( zebrakim@cnu.ac.kr )
2001-present Professor, Department of Biology, Chungnam National University, South Korea
1998-2001 Visiting fellow, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, USA
1993-1997 PhD, Department of Pharmacology, Osaka University Medical School, Japan
1985-1992 BS, MS, Department of Genetic Engineering, Kyungpook National University, South Korea

Zebrafish as an animal model for biomedical research

Zebrafish have several advantages compared to other vertebrate models used in modeling human diseases, particularly for large-scale genetic mutant and therapeutic compound screenings, and other biomedical research applications. With the impactful developments of CRISPR and next-generation sequencing technology, disease modeling in zebrafish is accelerating the understanding of the molecular mechanisms of human genetic diseases. These efforts are fundamental for the future of precision medicine because they provide new diagnostic and therapeutic solutions. This review focuses on zebrafish disease models for biomedical research, mainly in developmental disorders, mental disorders, and metabolic diseases.


Exp Mol Med. 2021 Mar 1. doi: 10.1038/s12276-021-00571-5.
https://pubmed.ncbi.nlm.nih.gov/33649498/