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Socialized mitochondria: mitonuclear crosstalk in stress

  • 작성자

    Kyung Hwa Kim
  • 작성일자

    2024-07-22
  • 조회수

    888
Kyung Hwa Kim( kyungkim@dau.ac.kr )
2019-presentAssistant Professor, Department of Health Care & Science, College of Health Sciences, Dong-A University, South Korea
2017-2019Research Professor, Department of Physiology, College of Korean Medicine, Kyung Hee University, South Korea
2014-2017Postdoctoral Fellow, Leonard Davis School of Gerontology, University of Southern California, USA
2012-2014Postdoctoral Fellow, Institute for Systems Biology, USA
2007-2012PhD, Department of Biochemistry and Molecular Biology, College of Medicine, Seoul National University, South Korea
2004-2006MS, Department of Physiology , College of Medicine, Yonsei University, South Korea
2001-2002Nurse, Intensive Care Unit, Korea University Anam Hospital, South Korea
1997-2001BS, Department of Physiology , College of Nursing, Korea University, South Korea

Socialized mitochondria: mitonuclear crosstalk in stress

Traditionally, mitochondria are considered sites of energy production. However, recent studies have suggested that mitochondria are signaling organelles that are involved in intracellular interactions with other organelles. Remarkably, stressed mitochondria appear to induce a beneficial response that restores mitochondrial function and cellular homeostasis. These mitochondrial stress-centered signaling pathways have been rapidly elucidated in multiple organisms. In this review, we examine current perspectives on how mitochondria communicate with the rest of the cell, highlighting mitochondria-to-nucleus (mitonuclear) communication under various stresses. Our understanding of mitochondria as signaling organelles may provide new insights into disease susceptibility and lifespan extension.

Exp Mol Med. 2024 May;56(5):1033-1042. doi: 10.1038/s12276-024-01211-4.
https://pubmed.ncbi.nlm.nih.gov/38689084/