생화학분자생물학회입니다.
Socialized mitochondria: mitonuclear crosstalk in stress
작성자
Kyung Hwa Kim작성일자
2024-07-22조회수
888Kyung Hwa Kim( kyungkim@dau.ac.kr ) | ||
2019-present | Assistant Professor, Department of Health Care & Science, College of Health Sciences, Dong-A University, South Korea | |
2017-2019 | Research Professor, Department of Physiology, College of Korean Medicine, Kyung Hee University, South Korea | |
2014-2017 | Postdoctoral Fellow, Leonard Davis School of Gerontology, University of Southern California, USA | |
2012-2014 | Postdoctoral Fellow, Institute for Systems Biology, USA | |
2007-2012 | PhD, Department of Biochemistry and Molecular Biology, College of Medicine, Seoul National University, South Korea | |
2004-2006 | MS, Department of Physiology , College of Medicine, Yonsei University, South Korea | |
2001-2002 | Nurse, Intensive Care Unit, Korea University Anam Hospital, South Korea | |
1997-2001 | BS, Department of Physiology , College of Nursing, Korea University, South Korea |
Socialized mitochondria: mitonuclear crosstalk in stress
Traditionally, mitochondria are considered sites of energy production. However, recent studies have suggested that mitochondria are signaling organelles that are involved in intracellular interactions with other organelles. Remarkably, stressed mitochondria appear to induce a beneficial response that restores mitochondrial function and cellular homeostasis. These mitochondrial stress-centered signaling pathways have been rapidly elucidated in multiple organisms. In this review, we examine current perspectives on how mitochondria communicate with the rest of the cell, highlighting mitochondria-to-nucleus (mitonuclear) communication under various stresses. Our understanding of mitochondria as signaling organelles may provide new insights into disease susceptibility and lifespan extension.
Exp Mol Med. 2024 May;56(5):1033-1042. doi: 10.1038/s12276-024-01211-4.
https://pubmed.ncbi.nlm.nih.gov/38689084/