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Potential roles of stem cell marker genes in axon regeneration

  • 작성자

    Yongcheol Cho
  • 작성일자

    2021-03-23
  • 조회수

    3
Yongcheol Cho ( ycho77@korea.ac.kr )
2018 - present Associate Professor, Department of Life Sciences, Korea University, Republic of Korea
2015 - 2018 Assistant Professor, Department of Life Sciences, Korea University, Republic of Korea
2014 - 2015 Staff Scientist, Department of Anatomy and Neurobiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA
2010 - 2014 Postdoctoral Fellow, Department of Anatomy and Neurobiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA
2009 - 2010 Postdoctoral Fellow, School of Life Sciences, Seoul National University, Republic of Korea
2003 - 2009 PhD, School of Life Sciences, Seoul National University, Republic of Korea
2001 - 2003 MS, Department of Molecular Biology, Seoul National University, Republic of Korea
1996 - 2001 BS, Department of Molecular Biology, Seoul National University, Republic of Korea

Potential roles of stem cell marker genes in axon regeneration

  

 Axon regeneration is orchestrated by many genes that are differentially expressed in response to injury. Through a comparative analysis of gene expression profiling, injury-responsive genes that are potential targets for understanding the mechanisms underlying regeneration have been revealed. As the efficiency of axon regeneration in both the peripheral and central nervous systems can be manipulated, we suggest that identifying regeneration-associated genes is a promising approach for developing therapeutic applications in vivo. Here, we review the possible roles of stem cell marker- or stemness-related genes in axon regeneration to gain a better understanding of the regeneration mechanism and to identify targets that can enhance regenerative capacity.


Exp Mol Med. 2021 Jan 14;53(1):1-7. doi: 10.1038/s12276-020-00553-z
https://pubmed.ncbi.nlm.nih.gov/33446881