생화학분자생물학회

	Name: Sang-Jun Ha ( sjha@yonsei.ac.kr )
	2019-present	Affiliate Faculty, POSTECH
	2019-present	Professor, Yonsei University
	2014-2019	Associate Professor, Yonsei University
	2009-2014	Assistant Professor, Yonsei University
	2007-2009	Research Associate, Emory University School of Medicine, USA
	2004-2007	Postdoctoral fellow, Emory University School of Medicine, USA
	2001-2004	Postdoctoral fellow, POSTECH
	1998-2001	Ph.D., Division of Molecular and Life Sciences, POSTECH

Perspectives of immune checkpoint ligand expression
: regulation and clinical implication

In tumor microenvironment, expression of immune checkpoint ligands (ICLs) is prerequisite to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL expression frequently occurs in tumor cell-intrinsic manner, extrinsic factors derived from tumor microenvironment can fine-tune ICL expression by tumor cells or prompt non-tumor cells, including immune cells, to express ICLs. Considering extensive interaction between T cells and other immune cells within tumor microenvironment, ICL expression on immune cells can be as significant as ICLs on tumor cells in anti-tumor immune responses. Here we introduce factors, which contribute to induction of ICLs in either tumor cells or immune cells, and concise mechanisms relevant to their induction.


BMB Rep 2021 Jun 3;5347. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34078531/