생화학분자생물학회

	YOUN SOO CHOI ( younsoo94@snu.ac.kr )
	2015-present	Associated Professor, Professor, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
	2014-2015	Instructor, Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA
	2009-2014	Postdoctoral Fellow, Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA
	2003-2008	Ph.D., Center for Comparative Medicine, University of California, Davis, Davis, CA, USA

Transcriptional regulation of Tfh dynamics and the formation of immunological synapses

Inside germinal centers (GCs), antigen-specific B cells rely on precise interactions with immune cells and strategic localization between the dark and light zones to clonally expand, undergo affinity maturation, and differentiate into long-lived plasma cells or memory B cells. Follicular helper T (Tfh) cells, the key gatekeepers of GC-dependent humoral immunity, exhibit remarkable dynamic positioning within secondary lymphoid tissues and rely on intercellular interactions with antigen-presenting cells (APCs) during their differentiation and execution of B-cell-facilitating functions within GCs. In this review, we briefly cover the transcriptional regulation of Tfh cell differentiation and function and explore the molecular mechanisms governing Tfh cell motility, their interactions with B cells within GCs, and the impact of their dynamic behavior on humoral responses.

Pubmed reference and link address
Exp Mol Med. 2024 Jun;56(6):1365-1372. doi: 10.1038/s12276-024-01254-7.
https://pubmed.ncbi.nlm.nih.gov/38825646/