생화학분자생물학회

	Name: Martin S. Weber ( martin.weber@med.uni-goettingen.de )
	10/2021-present	Head of the Fraunhofer ITMP Göttingen: “Translational Neuroinflammation and High-Resolution Microscopy
	10/2018-present	Head of the interdisciplinary „Clinical Multiple Sclerosis Center“ of the University medical Centre Göttingen
	10/2013-present	W2 Professor for „Translational Neuroinflammation“ at the Institute of Neuropathology
	07/2013-12/2017	W2 Professor for „Translational Neuroinflammation“, tenure track, Institute of Neuropathology, University medical centre Göttingen
	12/2007-09/2012	Residency in Neurology, Postdoctoral-fellowship, Department of Neurology of the Technische Universität München
	07/2004-11/2007	Postdoctoral fellow, Department of Neurology, University of California, San Francisco (UCSF)
	01/2002-06/2004	Residency in Neurology, Postdoctoral-fellowship, Institute for Clincial Neuroimmunology, Department of Neurology of the Ludwig-Maximilians Universität München-Großhadern

Microglia-associated progression of multiple sclerosis: Target identification and therapeutic engagement in human in vitro models

In cooperation with Alica Blenkle & Anastasia Geladaris

Chronic progression of multiple sclerosis (MS) is likely to develop on the basis of a highly complex interaction of different mechanisms, which are probably already present at disease onset. While animal models have been instrumental in developing therapies for relapsing forms of MS, they have provided limited insight into the processes driving disease progression. To overcome these limitations, human in vitro models have emerged as powerful tools to dissect cellular mechanisms and identify novel therapeutic targets. In this review, we highlight advances in modeling MS progression, using human induced pluripotent stem cell (iPSC)-derived systems, with a particular focus on microglia as key mediators of neuroinflammation and neurodegeneration. We critically discuss the strengths and limitations of current iPSC-based microglia models, and their utility in target identification and therapeutic engagement. By emphasizing translational applications and methodological innovations, this review provides a framework for leveraging human in vitro models to better understand and therapeutically modulate microglia-associated progression in MS.


Exp Mol Med (2026). Doi: 10.1038/s12276-026-01647-w.
https://pubmed.ncbi.nlm.nih.gov/41688741/