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BMB Reports

Remodeling of host glycoproteins during bacterial infection

  • 작성자

    Won Ho Yang
  • 작성일자

    2021-11-29
  • 조회수

    2
Name: Won Ho Yang ( bionicwono@yonsei.ac.kr )
2019-present Assistant Professor, Department of Systems Biology, Yonsei University
2016-2019 Scientific Associate, SBP Discovery Institute / UC Santa Barbara
2009-2016 Senior Postdoctoral Associate, SBP Discovery Institute / UC Santa Barbara
2008-2009 Postdoctoral Associate, HHMI / UC San Diego
2003-2007 Ph.D., Department of Biology, Yonsei University

Remodeling of host glycoproteins during bacterial infection

Protein glycosylation is a common post-translational modification found in all living organisms and the modification in bacterial pathogens has a pivotal role in their infectious processes including pathogenicity, immune evasion, and host-pathogen interactions. Importantly, many key proteins of host immune systems are also glycosylated and bacterial pathogens notably modulate glycosylation on these host proteins to facilitate pathogenesis through the induction of abnormal host protein activity and abundance. In recent years, there is an increased interest in studying the regulation of host protein glycosylation caused by bacterial pathogens to fully understand bacterial pathogenesis. In this review, we focus on how bacterial pathogens regulate remodeling of host glycoproteins during infections to promote the pathogenesis.


BMB Rep. 2021 Oct 22;5459. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34674797/