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BMB Reports

Molecular targets of exercise mimetics and their natural activators

  • 작성자

    Sanguine Byun
  • 작성일자

    2021-11-29
  • 조회수

    2
Name: Sanguine Byun ( sanguine@yonsei.ac.kr )
2020-present Assistant Professor, Department of Biotechnology, Yonsei University
2016-2020 Assistant Professor, Division of Bioengineering, Incheon National University
2012-2016 Postdoctoral research fellow, Harvard Medical School and Massachusetts General Hospital, USA
2009-2012 Ph.D., Agricultural Biotechnology, Seoul National University

Molecular targets of exercise mimetics and their natural activators

Physical exercise can be an effective mean in preventing or ameliorating various diseases, including diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer. However, not everyone may be able to participate in exercise due to illnesses, age-related frailty, or difficulty in long-term behavioral change. An alternative option would be to utilize pharmacological interventions that can exert the positive effects of exercise training. Recent studies have identified signaling pathways associated with the benefits of physical activity and discovered exercise mimetics that can, to some extent, simulate the systemic impact of exercise. This review will describe the molecular targets for exercise mimetics and their effect on skeletal muscle and other tissues. We will also discuss the potential advantage of using natural products as a multi-targeting agent for mimicking the health-promoting effects of exercise.