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Understanding the molecular basis of anorexia and tissue wasting in cancer cachexia

  • 작성자

    Kweon Yu
  • 작성일자

    2022-07-19
  • 조회수

    76
Kweon Yu( kweonyu@kribb.re.kr )
2001-presentPrincipal Researcher, Dept. of Disease Target Research Center, KRIBB, South Korea
2004-presentProfessor, Dept. of Functional Genomics, University of Science and Technology, South Korea
2002-2015Adjunct Professor, Dept. of Biology, Chungnam National Univ. South Korea
1999-2001Staff Scientist, Shriners Hospitals for Children, California, USA
1994-1999Postdoctoral Researcher, University of California, San Diego, USA
1989-1994Ph.D. Bowling Green State University, Ohio, USA

Understanding the molecular basis of anorexia and tissue wasting in cancer cachexia

Cancer cachexia syndrome is a major cause of morbidity and mortality in cancer patients in the advanced stage. It is a devastating disorder characterized by nutritional impairment, weakness, and wasting, and it affects treatment success and quality of life. Two major symptoms of cancer cachexia are anorexia and weight loss. Weight loss in cachexia is not reversed through increased food intake, suggesting that anorexia and weight loss in cancer patients are regulated by independent molecular mechanisms. Although the wasting phenotype mostly occurs in skeletal muscle and adipose tissue, other organs, such as the brain, liver, pancreas, heart, and gut, are also involved in cachexia. Thus, cachexia is a multiorgan syndrome. Although the molecular basis of cancer cachexiainduced weight loss is known, the mechanism underlying anorexia is poorly understood. Here, we highlight our recent discovery of a new anorexia mechanism by which a tumor-derived humoral factor induces cancer anorexia by regulating feeding-related neuropeptide hormones in the brain. Furthermore, we elucidated the process through which anorexia precedes tissue wasting in cachexia. This review article aims to provide an overview of the key molecular mechanisms of anorexia and tissue wasting caused by cancer cachexia

Experimental & Molecular Medicine (2022) 54:426–432;
https://doi.org/10.1038/s12276-022-00752-w