생화학분자생물학회

	Name: Chan Chung ( chungc@dgist.ac.kr )
	2021-present	Assistant Professor, Department of New Biology, DGIST
	2020-2021	Research Investigator, University of Michigan, Medical School, USA
	2015-2020	Postdoctoral research fellow, University of Michigan, Medical School, USA
	2010-2015	Ph.D., Department of Molecular and Cellular Pathology, University of Michigan, Medical School, USA
	Name: JaeHyung Koo ( jkoo001@dgist.ac.kr )
	2017-present	Professor, Dept. of New Biology, DGIST
	2017-2018	Associated Vice-President for Research Affairs, DGIST
	2011-2016	Visiting Professor, Johns Hopkins University Sch. of Medicine, Baltimore
	2010-2017	Associate Professor, Dept. of Brain & Cognitive Sciences, DGIST
	2003-2008	Assistant Professor, Dept. of Anatomy and Neurobiology Univ. of Maryland Sch. of Medicine, Baltimore, MD, USA
	2000-2003	Postdoc. Fellow, Univ. of Maryland Sch. of Medicine, Baltimore
	1997-2000	Ph.D., Department of Biochemistry, Yonsei University

Odorant receptors in cancer

Odorant receptors (ORs), the largest subfamily of G proteincoupled receptors, detect odorants in the nose. In addition, ORs were recently shown to be expressed in many nonolfactory tissues and cells, indicating that these receptors have physiological and pathophysiological roles beyond olfaction. Many ORs are expressed by tumor cells and tissues, suggesting that they may be associated with cancer progression or may be cancer biomarkers. This review describes OR expression in various types of cancer and the association of these receptors with various types of signaling mechanisms. In addition, the clinical relevance and significance of the levels of OR expression were evaluated. Namely, levels of OR expression in cancer were analyzed based on RNA-sequencing data reported in the Cancer Genome Atlas; OR expression patterns were visualized using t-distributed stochastic neighbor embedding (t-SNE); and the associations between patient survival and levels of OR expression were analyzed. These analyses of the relationships between patient survival and expression patterns obtained from an open mRNA database in cancer patients indicate that ORs may be cancer biomarkers and therapeutic targets.


BMB Reports 2022; 55(2): 72-80
https://pubmed.ncbi.nlm.nih.gov/35168702/