생화학분자생물학회

	Daolin Tang( Daolin.tang@utsouthwestern.edu )
	2018-present	Associate Professor, Department of Surgery, UT Southwestern Medical Center, USA
	2016-2018	Associate Professor, Department of Surgery, University of Pittsburgh, USA
	2012-2015	Assistant Professor, Department of Surgery, University of Pittsburgh, USA
	2010-2012	Research Assistant Professor, Department of Surgery, University of Pittsburgh, USA
	2007-2009	Postdoctoral Fellow, Department of Surgery, University of Pittsburgh, USA
	2002-2007	PhD, Department of Pathophysiology, Xiangya School of Medicine, Central South University, China
	2000-2002	Teaching Assistant, Department of Pathophysiology, Xiangya School of Medicine, Central South University, China
	1995-2000	MD, Norman Bethune College of Medicine, Jilin University, China

The mechanism of HMGB1 secretion and release

High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes. In the cytoplasm, HMGB1 can promote autophagy by binding to BECN1 protein. After its active secretion or passive release, extracellular HMGB1 usually acts as a damage-associated molecular pattern (DAMP) molecule, regulating inflammation and immune responses through different receptors or direct uptake. The secretion and release of HMGB1 is fine-tuned by a variety of factors, including its posttranslational modification (e.g., acetylation, ADP-ribosylation, phosphorylation, and methylation) and the molecular machinery of cell death (e.g., apoptosis, pyroptosis, necroptosis, alkaliptosis, and ferroptosis). In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these topics may help us develop new HMGB1-targeted drugs for various conditions, especially inflammatory diseases and tissue damage.

Exp Mol Med. 2022 Feb 25. doi: 10.1038/s12276-022-00736-w.
https://pubmed.ncbi.nlm.nih.gov/35217834/