생화학분자생물학회

	Name: Byung-Chul Lee ( bclee@sookmyung.ac.kr )
	2023-present	Assistant Professor, Division of Biological Sciences, Sookmyung Women’s University
	2019-2023	Postdoc fellow, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA
	2019-2019	Postdoc fellow, Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
	2012-2019	Ph.D., Veterinary Medicine, Seoul National University, Seoul, Republic of Korea

Challenges and innovations in hematopoietic stem cell transplantation: exploring bone marrow niches and new model systems

Hematopoietic stem cell transplantation (HSCT) remains an indispensable therapeutic strategy for various hematological diseases. This review discusses the pivotal role of bone marrow (BM) niches in influencing the efficacy of HSCT and evaluates the current animal models, emphasizing their limitations and the need for alternative models. Traditional animal models, mainly murine xenograft, have provided significant insights, but due to species-specific differences, are often constrained from accurately mimicking human physiological responses. These limitations highlight the importance of developing alternative models that can more realistically replicate human hematopoiesis. Emerging models that include BM organoids and BM-on-a-chip microfluidic systems promise enhanced understanding of HSCT dynamics. These models aim to provide more accurate simulations of the human BM microenvironment, potentially leading to improved preclinical assessments and therapeutic outcomes. This review highlights the complexities of the BM niche, discusses the limitations of current models, and suggests directions for future research using advanced model systems.


BMB Rep. 2024 Aug;57(8):352-362
https://pubmed.ncbi.nlm.nih.gov/38919014/