생화학분자생물학회

	Name: Soohwan Oh ( soohwanoh@korea.ac.kr )
	2022-	Assistant Professor in College of Pharmacy, Korea Univ. Korea University, Sejong, South Korea
	2018-2022	Postdoctoral research fellow, University of California, San Diego, CA
	2012-2018	Ph.D., Biological Science Graduate Program, University of California, San Diego, CA

DNA regulatory element cooperation and competition in transcription

Regulation of eukaryotic transcription is a complex process that enables precise temporal and spatial control of gene expression. Promoters, which are cis-regulatory elements (CREs) located proximal to the transcription start site (TSS), selectively integrate regulatory cues from distal CREs, or enhancers, and their associated transcriptional machinery. In this review, we discuss current knowledge regarding cooperation and competition between CREs impacting gene expression, including features of enhancer-promoter, enhancer-enhancer, and promoter-promoter interplay. We also provide an overview of recent insights into the underlying molecular mechanisms, such as the involvement of enhancer RNAs and biomolecular condensates, that facilitate physical and functional regulatory element interactions.


BMB Rep. 2024 Nov 11:6251. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/39523506/