생화학분자생물학회

	Seung-Hoi Koo ( koohoi@korea.ac.kr )
	2013-present	Professor, Division of Life Sciences, Korea University, Korea
	2005-2013	Assistant/Associate Professor, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Korea
	2002-2005	Research Associate, Salk Institute for Biological Studies, USA
	2001-2002	Postdoctoral Associate, Department of Molecular Pharmacology, Stanford University, USA
	2000-2001	Postdoctoral Associate, BMBB graduate program, University of Minnesota, USA
	1995-2000	PhD. BMBB graduate program, University of Minnesota, USA
	1993-1995	MS. Department of Chemistry, Seoul National University, Korea
	1988-1992	BS. Department of Chemistry, Seoul National University, Korea

The role of BCAA metabolism in metabolic health and disease

It has long been postulated that dietary restriction is beneficial for ensuring longevity and extending the health span of mammals, including humans. In particular, a reduction in protein consumption has been shown to be specifically linked to the beneficial effect of dietary restriction on metabolic disorders, presumably by reducing the activity of the mechanistic target of rapamycin complex (mTORC) 1 and the reciprocal activation of AMP-activated protein kinase (AMPK) and sirtuin pathways. Although it is widely used as a dietary supplement to delay the aging process in humans, recent evidence suggests that branched-chain amino acids (BCAAs) might be a major cause of the deteriorating effect of a protein diet on aging and related disorders. In this review, we delineate the regulation of metabolic pathways for BCAAs at the tissue-specific level and summarize recent findings regarding the role of BCAAs in the control of metabolic health and disease in mammals.

Exp Mol Med. 2024 Jul;56(7):1552-1559. doi: 10.1038/s12276-024-01263-6.
https://pubmed.ncbi.nlm.nih.gov/38956299/