생화학분자생물학회

	Chang-il Hwang ( cihwang@ucdavis.edu )
	2018-present	Assistant Professor, Microbiology and Molecular Genetics, College of Biological Sciences, University of California Davis
	2012-2018	Postdoctoral Fellow, Cold Spring Harbor Laboratory
	2011-2012	Postdoctoral Associated, Biomedical Sciences, Cornell University
	2006-2011	PhD, Cornell University
	2001-2003	MS, College of Medicine, Seoul National University
	1996-2000	DVM, College of Veterinary Medicine, Seoul National University

Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology

Research on pancreatic cancer has transformed with the advent of organoid technology, providing a better platform that closely mimics cancer biology in vivo. This review highlights the critical advancements facilitated by pancreatic organoid models in understanding disease progression, evaluating therapeutic responses, and identifying biomarkers. These three-dimensional cultures enable the proper recapitulation of the cellular architecture and genetic makeup of the original tumors, providing insights into the complex molecular and cellular dynamics at various stages of pancreatic ductal adenocarcinoma (PDAC). We explore the applications of pancreatic organoids in dissecting the tumor microenvironment (TME); elucidating cancer progression, metastasis, and drug resistance mechanisms; and personalizing therapeutic strategies. By overcoming the limitations of traditional 2D cultures and animal models, the use of pancreatic organoids has significantly accelerated translational research, which is promising for improving diagnostic and therapeutic approaches in clinical settings, ultimately aiming to improve the outcomes of patients with pancreatic cancer.

Exp Mol Med. 2025 Feb;57(1):50-58. doi: 10.1038/s12276-024-01378-w.
https://pubmed.ncbi.nlm.nih.gov/39814914/