생화학분자생물학회

	Name: Hye Ji Cha ( hyejicha@dankook.ac.kr )
	2023-present	Assistant Professor, Department of Biomedical Science & Engineering, Dankook University
	2022-2023	Instructor, Harvard Medical School, USA
	2014-2022	Research fellow, Boston Children’s Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, USA
	2008-2014	Ph.D., the Institute for Cellular and Molecular Biology, University of Texas at Austin, USA

Nuclear structures and their emerging roles in cell differentiation and development

The nucleus, a highly organized and dynamic organelle, plays a crucial role in regulating cellular processes. During cell differentiation, profound changes occur in gene expression, chromatin organization, and nuclear morphology. This review explores the intricate relationship between nuclear architecture and cellular function, focusing on the roles of the nuclear lamina, nuclear pore complexes (NPCs), sub-nuclear bodies, and the nuclear scaffold. These components collectively maintain nuclear integrity, organize chromatin, and interact with key regulatory factors. The dynamic remodeling of chromatin, its interactions with nuclear structures, and epigenetic modifications work in concert to modulate gene accessibility and ensure precise spatiotemporal control of gene expression. The nuclear lamina stabilizes nuclear shape and is associated with inactive chromatin regions, while NPCs facilitate selective transport. Sub-nuclear bodies contribute to genome organization and gene regulation, often by influencing RNA processing. The nuclear scaffold provides structural support, impacting 3D genome organization, which is crucial for proper gene expression during differentiation. This review underscores the significance of nuclear architecture in regulating gene expression and guiding cell differentiation. Further investigation into nuclear structure and 3D genome organization will deepen our understanding of the mechanisms governing cell fate determination.


BMB Rep. 2024 Sep;57(9):381-387
https://pubmed.ncbi.nlm.nih.gov/39219044/