생화학분자생물학회

	Jun-An Chen ( jac2210@gate.sinica.edu.tw )
	2023-present	Research Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan
	2019-2023	Associate Research Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan
	2012-2019	Assistant Research Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan
	2007-2012	Postdoc, Department of Pathology, Columbia University, USA
	2002-2006	PhD, The Gurdon Institute, Cambridge University, UK

Elucidation of how the Mir-23-27-24 cluster regulates development and aging

MicroRNAs (miRNAs) are pivotal regulators of gene expression and are involved in biological processes spanning from early developmental stages to the intricate process of aging. Extensive research has underscored the fundamental role of miRNAs in orchestrating eukaryotic development, with disruptions in miRNA biogenesis resulting in early lethality. Moreover, perturbations in miRNA function have been implicated in the aging process, particularly in model organisms such as nematodes and flies. miRNAs tend to be clustered in vertebrate genomes, finely modulating an array of biological pathways through clustering within a single transcript. Although extensive research of their developmental roles has been conducted, the potential implications of miRNA clusters in regulating aging remain largely unclear. In this review, we use the Mir-23-27-24 cluster as a paradigm, shedding light on the nuanced physiological functions of miRNA clusters during embryonic development and exploring their potential involvement in the aging process. Moreover, we advocate further research into the intricate interplay among miRNA clusters, particularly the Mir-23-27-24 cluster, in shaping the regulatory landscape of aging.

Experimental & Molecular Medicine volume 56, pages 1263–1271 (2024)
https://pubmed.ncbi.nlm.nih.gov/38871817/