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Erythropoiesis: insights from a genomic perspective

  • 작성자

    Hye Ji Cha
  • 작성일자

    2024-12-26
  • 조회수

    396
Hye Ji Cha ( hyejicha@dankook.ac.kr )
2023-presentAssistant Professor, Department of Biomedical Science & Engineering, Dankook University, South Korea
2022-2023Instructor, Pediatrics, Harvard Medical School, USA
2014-2022Research Fellow, Boston Children’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, USA
2008-2014Ph.D., Institute for Cellular and Molecular Biology, University of Texas at Austin, USA
2006-2008M.S., Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), South Korea
2002-2006B.S., Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), South Korea

Erythropoiesis: insights from a genomic perspective

Erythropoiesis, the process underlying the production of red blood cells, which are essential for oxygen transport, involves the development of hematopoietic stem cells into mature red blood cells. This review focuses on the critical roles of transcription factors and epigenetic mechanisms in modulating gene expression critical for erythroid differentiation. It emphasizes the significance of chromatin remodeling in ensuring gene accessibility, a key factor for the orderly progression of erythropoiesis. This review also discusses how dysregulation of these processes can lead to erythroid disorders and examines the promise of genome editing and gene therapy as innovative therapeutic approaches. By shedding light on the genomic regulation of erythropoiesis, this review suggests avenues for novel treatments for hematological conditions, underscoring the need for continued molecular studies to improve human health.

Exp Mol Med. 2024 Oct;56(10):2099-2104. doi: 10.1038/s12276-024-01311-1.
https://pubmed.ncbi.nlm.nih.gov/39349824