생화학분자생물학회

	Name: Donghyuk Shin ( donghyuk.shin@yonsei.ac.kr )
	2021-present	Assistant Professor, Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Korea
	2020-2021	Assistant Professor, Department of Bioengineering, Incheon National University, Korea
	2017-2020	Postdoctoral research fellow, Max-Planck Institute of Biophysics & BMLS Goethe University, Germany
	2012-2017	Ph.D., Department of Biological Sciences, Sungkyunkwan University, Korea

Ubiquitin regulating effector proteins from Legionella

Ubiquitin is relatively modest in size but involves almost entire cellular signaling pathways. The primary role of ubiquitin is maintaining cellular protein homeostasis. Ubiquitination regulates the fate of target protein through the proteasome or autophagy-mediated degradation of ubiquitinated substrates. These substrates can be either intracellular or foreign proteins from invading pathogens. Legionella, a gram-negative intracellular pathogen, hinders the host-ubiquitin system by translocating dozens of effector proteins into the host cytosol. This review describes the current understanding of ubiquitin machinery from Legionella. We summarize structural and biochemical differences between the host-ubiquitin system and ubiquitin-related effectors of Legionella. Some of these effectors act almost similar to canonical host-ubiquitin machinery, while others have distinctive structures and perform noncanonical ubiquitination through novel biochemical mechanisms.


BMB Rep. 2022 Jun 2;5601. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35651329/