생화학분자생물학회

	Name: Seung-Soon Im ( ssim73@kmu.ac.kr )
	2012-present	Professor, Department of Physiology, Keimyung University School of Medicine
	2009-2012	Staff Scientist, Sanford Burnham Presby Medical Research Institute, USA
	2007-2009	Postdoctoral research fellow, University of California, Irvine, USA
	2006-2007	Research Instructor, Yonsei University School of Medicine, Korea
	2002-2006	Ph.D., Yonsei University, Korea
	Name: Jae-Ho Lee ( hoyaya86@naver.com )
	2020-present	Postdoctoral Fellow, Department of Physiology, Keimyung University School of Medicine
	2016-2020	Ph.D., Department of Physiology, Keimyung University School of Medicine
	2013-2015	M.S., Department of Physiology, Keimyung University School of Medicine
	2005-2012	B.S., Department of Biotechnology, Konkuk University

Function of gaseous hydrogen sulfide in liver disease

Over the past few years, hydrogen sulfide (H2S) has been shown to exert several biological functions in mammalian. The endogenous production of H2S is mainly mediated by cystathione β-synthase (CBS), cystathione γ-lyase (CSE) and 3-mercaptopyruvate sulfur transferase (MPST). These enzymes are broadly expressed in liver tissue and regulates liver function by working on a variety of molecular targets. As an important regulator of liver function, H2S is critically involved in the pathogenesis of various liver diseases, such as non-alcoholic steatohepatitis (NASH), liver fibrosis and liver cancer. Targeting H2S-generating enzymes may be a therapeutic strategy for controlling liver diseases. This review described the function of H2S in liver disease and summarized recent characterized role of H2S in several cellular process of the liver.


BMB Rep. 2022 Oct;55(10):481-487. DOI: 10.5483/BMBRep.2022.55.10.124.​

https://pubmed.ncbi.nlm.nih.gov/36195563/