생화학분자생물학회

	Name: Jeong-Hoon Hahm (hahmjh@kfri.re.kr)
	2020-present	Researcher, Korea Food Research Institute, Korea
	2013-2020	Research Fellow, Section Leader, Center for Plant Aging Research Institute for Basic Science, Korea
	2012-2013	Postdoctoral research fellow, Buck Institute for Research on Aging, USA
	2010-2012	Postdoctoral research fellow, Yonsei Proteome Research Center, Korea
	2006-2010	Ph.D., Department of Biochemistry, Yonsei University, Korea

Longevity through diet restriction and immunity

The share of the population that is aging is growing rapidly. In an aging society, technologies and interventions that delay the aging process are of great interest. Dietary restriction (DR) is the most reproducible and effective nutritional intervention tested to date for delaying the aging process and prolonging the health span in animal models. Preventive effects of DR on age-related diseases have also been reported in human. In addition, highly conserved signaling pathways from small animal models to human mediate the effects of DR. Recent evidence has shown that the immune system is closely related to the effects of DR, and functions as a major mechanism of DR in healthy aging. This review discusses the effects of DR in delaying aging and preventing age-related diseases in animal, including human, and introduces the molecular mechanisms that mediate these effects. In addition, it reports scientific findings on the relationship between the immune system and DRinduced longevity. The review highlights the role of immunity as a potential mediator of the effects of DR on longevity, and provides insights into healthy aging in human.


BMB Rep. 2023 Oct;56(10):537-544. doi: 10.5483/BMBRep.2023-0095
https://pubmed.ncbi.nlm.nih.gov/37482753/