생화학분자생물학회

	Name: Daeho Park (daehopark@gist.ac.kr)
	2012-present	Professor, School of Life Sciences, GIST, Republic of Korea
	2008-2012	Research Associate, Department of immunology and infectious disease, School of Medicine, University of Virginia, USA
	2004-2008	PhD, Department of Cell Biology, School of Medicine, University of Virginia, USA
	2003-2004	Researcher, School of Life Sciences, GIST, Republic of Korea
	2001-2003	MS, School of Life Sciences, GIST, Republic of Korea
	1994-2001	BS, Food Science and Technology, Seoul National University, Republic of Korea

After cell death: the molecular machinery of efferocytosis

Cells constituting a multicellular organism die in a variety of ways throughout life, and most of them die via apoptosis under normal conditions. The occurrence of apoptosis is especially prevalent during development and in tissues with a high cellular turnover rate, such as the thymus and bone marrow. Interestingly, although the number of apoptotic cells produced daily is known to be innumerable in a healthy adult human body, apoptotic cells are rarely observed. This absence is due to the existence of a cellular process called efferocytosis that efficiently clears apoptotic cells. Studies over the past decades have focused on how phagocytes are able to remove apoptotic cells specifically, swiftly, and continuously, resulting in defined molecular and cellular events. In this review, we will discuss the current understanding of the clearance of apoptotic cells at the molecular level.


Exp Mol Med. 2023 Aug; 55(8): 1644–1651.
https://pubmed.ncbi.nlm.nih.gov/37612408/