생화학분자생물학회

	Name: Ki-Tae Ha (hagis@pusan.ac.kr)
	2019-present	Professor, School of Korean Medicine, Pusan National University
	2014-2021	Director, Korean Medicine Research Center for Healthy Aging (MRC)
	2014-2019	Associated Professor, School of Korean Medicine, Pusan National University
	2014-2016	Chair, Department of Korean Medical Science, Pusan National University
	2010-2014	Assistant Professor, School of Korean Medicine, Pusan National University
	2004-2010	Director, Hana Korean Medical Clinic
	2002-2004	PhD, Department of Korean Medicine, Dongguk University
	1999-2001	MS, Department of Korean Medicine, Dongguk University
	1992-1999	KMD, Department of Korean Medicine, Dongguk University

Diversity and complexity of cell death: a historical review

Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome of nonfunctioning cells, as inflammation was inevitably triggered in response to damage. However, experimental evidence accumulated over the past few decades has revealed different types of cell death that are genetically programmed to eliminate unnecessary or severely damaged cells that may damage surrounding tissues. Several types of cell death, including apoptosis, necrosis, autophagic cell death, and lysosomal cell death, which are classified as programmed cell death, and pyroptosis, necroptosis, and NETosis, which are classified as inflammatory cell death, have been described over the years. Recently, several novel forms of cell death, namely, mitoptosis, paraptosis, immunogenic cell death, entosis, methuosis, parthanatos, ferroptosis, autosis, alkaliptosis, oxeiptosis, cuproptosis, and erebosis, have been discovered and advanced our understanding of cell death and its complexity. In this review, we provide a historical overview of the discovery and characterization of different forms of cell death and highlight their diversity and complexity. We also briefly discuss the regulatory mechanisms underlying each type of cell death and the implications of cell death in various physiological and pathological contexts. This review provides a comprehensive understanding of different mechanisms of cell death that can be leveraged to develop novel therapeutic strategies for various diseases.


Exp Mol Med. 2023 Sep;55(9):2083. doi: 10.1038/s12276-023-01107-9.
https://pubmed.ncbi.nlm.nih.gov/37612413/