생화학분자생물학회입니다.
Understanding the contextual functions of C1q and LAIR-1 and their applications
작성자
Myoungsun Son작성일자
2022-07-19조회수
90Myoungsun Son( mson@northwell.edu ) | ||
2017-present | Assistant Professor, Department of Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, New York, USA | |
2014-present | Assistant Professor, The Feinstein Institutes for Medical Research, New York, USA | |
2008-2014 | Post. Doc. The Feinstein Institutes for Medical Research, New York, USA | |
2007-2008 | Research Professor, Ewha Womans University, South Korea | |
2005-2007 | Post. Doc. Department of Molecular Life Science, Ewha Womans University, South Korea | |
2000-2005 | PhD, Department of Molecular Life Science, Ewha Womans University, South Korea | |
1995-1999 | BS, Department of Natural Science, Kyunghee University, South Korea |
Understanding the contextual functions of C1q and LAIR-1 and their applications
The importance of the complement component C1q has been highlighted by its involvement in autoimmunity, infection, inflammatory diseases, and tumors. The unique tulip-like structure of C1q has both a collagen-like stalk (C1q tail) and heterotrimeric globular head (gC1q), each with different binding specificities, and the binding of these components to their respective receptors leads to functional complexities in the body and bridges innate and adaptive immunity. This review describes the fundamental roles of C1q in various microenvironments and focuses on the importance of the interactions of C1q and its receptors with the inhibitory receptor LAIR-1 in maintaining homeostasis. Current therapeutic opportunities modulating LAIR-1 are also discussed.
Exp Mol Med. 2022 May;54(5):567-572. doi: 10.1038/s12276-022-00774-4.
https://pubmed.ncbi.nlm.nih.gov/3556258