생화학분자생물학회

	Young-Pil Kim ( ypilkim@hanyang.ac.kr )
	2019 - present	Professor, Department of Life Science, Hanyang University, Korea
	2011 - 2019	Assistant~Associate Professor, Department of Life Science, Hanyang University, Korea
	2017 - 2018	Visiting Professor, Department of Bioengineering, University of Washington, USA
	2008 - 2011	Postdoctoral Affiliate, School of Medicine, Stanford University, USA
	2002 - 2008	Ph.D. Department of Biological Sciences, KAIST, Korea

Tailoring photosensitive ROS for advanced photodynamic therapy

Photodynamic therapy (PDT) has been considered a noninvasive and cost-effective modality for tumor treatment. However, the complexity of tumor microenvironments poses challenges to the implementation of traditional PDT. Here, we review recent advances in PDT to resolve the current problems. Major breakthroughs in PDTs are enabling significant progress in molecular medicine and are interconnected with innovative strategies based on smart bio/nanomaterials or therapeutic insights. We focus on newly developed PDT strategies designed by tailoring photosensitive reactive oxygen species generation, which include the use of proteinaceous photosensitizers, self-illumination, or oxygen-independent approaches. While these updated PDT platforms are expected to enable major advances in cancer treatment, addressing future challenges related to biosafety and target specificity is discussed throughout as a necessary goal to expand the usefulness of PDT.

Exp Mol Med. 2021 Apr;53(4):495-504. doi: 10.1038/s12276-021-00599-7.
https://pubmed.ncbi.nlm.nih.gov/33833374/